It is one of Cagliari’s monumental churches. Sant'Antonio Abate is located in the historical district of Marina, in Via Manno, one of the capital's most famous streets, where you can combine a historical-cultural visit with some shopping. The current building dates back to the 18th century and stands on the site of pre-existing building, namely the chapel of an ancient hospital, dating back to the 14th century, and an integral part of a convent.

The façade has a large mixtilinear portal with a rich cornice decorated with mouldings, bearing the coat of arms of the Spedalieri di San Giovanni di Dio (Hospitallers of St John of God). Over it, there is a niche containing the statue of the saint, next to which there is a piglet, demonstrating the saint's devotion towards wayfarers and animals. At one time, it was customary to bring animals here on 17 January, on the anniversary in celebration of the saint, to have them blessed.

The interior has an octagonal layout with a dome roof and six lateral chapels, framed by parastades and with barrel vaults. The decoration is late Baroque style, with green plasterwork, on which golden stuccoes stand out. In the presbytery, there is a multi-coloured marble altar. Both that in the presbytery and the alters of the two chapels are the work of the sculptor Giovanbattista Troiani, while the exquisite paintings, among which one from the Sixteenth century, dedicated to the Madonna of Itria, are attributed to Ursino Buoncora. Along the portico of Sant'Antonio, that joins the church to the ancient hospital, you can see the remains of blocked openings, as well as a series of medieval coats of arms set in the wall.

From via Manno, you can continue your visit to Cagliari's historical districts: from the fortifications and bastions of Castello, to the little alleys and monuments of Stampace, the elegant streets and other ancient and modern religious buildings of Villanova and the quaint roads full of typical local restaurants in the Marina, overlooking the port with the splendid buildings in Via Roma, among which Palazzo Civico.