It is one of Cagliari’s monumental churches. Sant'Antonio Abate is located in the historical district of Marina, in Via Manno, one of the capital's most famous streets, where you can combine a historical-cultural visit with some shopping. The current building dates back to the 18th century and stands on the site of pre-existing building, namely the chapel of an ancient hospital, dating back to the 14th century, and an integral part of a convent.

The façade has a large mixtilinear portal with a rich cornice decorated with mouldings, bearing the coat of arms of the Spedalieri di San Giovanni di Dio (Hospitallers of St John of God). Over it, there is a niche containing the statue of the saint, next to which there is a piglet, demonstrating the saint's devotion towards wayfarers and animals. At one time, it was customary to bring animals here on 17 January, on the anniversary in celebration of the saint, to have them blessed.